Eradication of Glioblastoma Multiforme stem-cells with Immunotargeted-molecular-robotic-NANOSURGERY (ITMRN)
نویسندگان
چکیده
منابع مشابه
Glioblastoma Multiforme Stem Cells
Glioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapie...
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Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...
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AIM To identify and characterize cancer stem cells (CSC) in glioblastoma multiforme (GBM). METHODS Four-micrometer thick formalin-fixed paraffin-embedded GBM samples from six patients underwent 3,3-diaminobenzidine (DAB) and immunofluorescent (IF) immunohistochemical (IHC) staining for the embryonic stem cell (ESC) markers NANOG, OCT4, SALL4, SOX2, and pSTAT3. IF IHC staining was performed to...
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Glioblastoma multiforme (GBM), an aggressive brain tumor of astrocytic/neural stem cell origin, represents one of the most incurable cancers. GBM tumors are highly heterogeneous. However, most tumors contain a subpopulation of cells that display neural stem cell characteristics in vitro and that can generate a new brain tumor upon transplantation in mice. Hence, previously identified molecular ...
متن کاملBrain tumor stem cells from an adenoid glioblastoma multiforme.
Brain tumors may arise from and contain cancer stem cells (CSCs) capable of self-renewal, proliferation, and differentiation that recapitulate the parent tumor. These CSCs are thought to be important in gliomagenesis. Detection of CSCs invading the adjacent brain regions is important for the diagnosis and effective treatment of glioblastoma multiforme (GBM). A 57-year-old man presented with an ...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2018
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nox237.023